Variant Gene Responsible for the Amount of Coffee You Drink

A new study seems to have found a possible link between how much coffee an individual consumes and their genetic makeup.

There are a lot of people out there who wonder why some only need to drink a cup or two of coffee while others need to consume several cups per day. A lot of research has been done in order to find the relationship between a person’s craving for coffee and their genetic makeup. There is also evidence that the amount of coffee an individual drinks per day has a genetic reason rather than the amount of sleep they were able to get the night before.


According to researchers, after tea and water, coffee is the most popular beverage around the world. Drinking coffee has also been linked to a lot of health benefits for human beings. There is scientific evidence that show coffee consumption to give rise to health benefits which include the improvement of short-term memory, and reducing the risks of melanoma, multiple sclerosis, liver cancer, and even Type 2 diabetes. Coffee has also been proven to be an effective method of mental stress relief. Some studies suggest that drinking coffee is also good for your heart.


For those of you who might not know, studies trying to find the link between coffee cravings and genetics date way back to the 1960s. It was in 1962 that researchers found a possible hereditary factor behind a person’s coffee drinking habits. Recently, large scale studies have been conducted. The results from such studies have shown an association present between a few genes and the amount of coffee consumed by people.

A gene variant has been discovered in a new paper. The study was published in Scientific Reports and it says that coffee drinking seems to be limited by the newly discovered gene variant. According to the authors of the study, that took into account 1,200 people living in Italy, individuals who had the PDSS2 genetic variant craved fewer cups of coffee per day compared to individuals who didn’t have the variant. Upon further analysis the researchers found out that the PDSS2 gene’s expression seems to limit the body’s ability to break down caffeine. This means that people with such a genetic variant crave few cups of coffee to get a strong ‘caffeine jolt’ because it takes time for them to break down caffeine and thus, it stays longer inside them.

“People with a higher consumption of coffee have a lower expression of PDSS2,” said the research team, as genes with lower expression are less active.

In order to further confirm their findings, the study was replicated in a group that consisted of 1,731 individuals from Netherlands. While the replicated study showed the results to be similar the overall effect on the number of cups of coffee consumed by people was a bit lower.

The authors of the current paper are confident that they have been able to identify a gene that was previously not linked to drinking coffee. However, they still want to replicate their findings on an even larger scale.


“The results of our study add to existing research suggesting that our drive to drink coffee may be embedded in our genes,” said the first author Nicola Piratsu. He is also a genetics researcher at the University of Edinburgh in Scotland.

More research is required to further cement the possible link between the discovered gene variant and coffee consumption.

Category: News

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Article by: Douglas Norman

Douglas writes all the latest health news for BodyFatLoss. He is very diligent about finding all the facts and sources of any new health and fitness findings.